VonWillebrand Disease type 1 (vWD1):
Von Willebrand disease (vWD) is an inherited bleeding disorder that inhibits the normal blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience excessive bruising, prolonged nosebleeds, and excessive bleeding following any form of trauma, including surgery, or dental work.
The primary function of von Willebrand factor (vWF) a blood glycoprotein, is to bind itself to other proteins. The deficiency or failure of vWF function inhibits the blood coagulation process and causes bleeding which is most apparent in tissues having high blood flow or narrow vessels.
Von Willebrand's disease type I (vWDI):
In dogs (as well as in people), three separate types of vWD have been identified. Of these three types there are five different genetic mutations causing vWDs in dogs. Genetic tests have been developed to identify all five variants. Von Willebrand's disease type I (VWDI) is transmitted as an autosomal recessive trait with variable penetrance and is the least serious of the three.
The causal mutation for VWDI is a G>A substitution. The mutation reduces the normal production of von Willebrand's factor (vWf) in affected dogs to only 5-10% of normal vWf production. This low concentration of normal vWf prevents normal blood coagulation resulting in excessive bleeding.
Requires both parents to have or carry the gene for vWD1. vWD1 is a recessive disorder and a dog must have two copies of this mutation for the disease to manifest. This means that a dog can have one copy of the mutation and not experience any signs or symptoms of vWD1; this dog would be known as a carrier. The carrier can then pass on either the normal gene or the mutated gene to any offspring. If two carriers are bred, a dog could potentially receive the mutated gene from each parent and be affected by vWD1.
Symptoms include: Abnormal Bleeding, Abnormal Blood Clotting, Bleeding Gums, Blood In The Feces, Blood In The Urine, Easy Bruising, Excessive Bleeding, Hematochezia, Hematoma, Hematuria, Nosebleeds, Vaginal Bleeding.
The primary function of von Willebrand factor (vWF) a blood glycoprotein, is to bind itself to other proteins. The deficiency or failure of vWF function inhibits the blood coagulation process and causes bleeding which is most apparent in tissues having high blood flow or narrow vessels.
Von Willebrand's disease type I (vWDI):
In dogs (as well as in people), three separate types of vWD have been identified. Of these three types there are five different genetic mutations causing vWDs in dogs. Genetic tests have been developed to identify all five variants. Von Willebrand's disease type I (VWDI) is transmitted as an autosomal recessive trait with variable penetrance and is the least serious of the three.
The causal mutation for VWDI is a G>A substitution. The mutation reduces the normal production of von Willebrand's factor (vWf) in affected dogs to only 5-10% of normal vWf production. This low concentration of normal vWf prevents normal blood coagulation resulting in excessive bleeding.
Requires both parents to have or carry the gene for vWD1. vWD1 is a recessive disorder and a dog must have two copies of this mutation for the disease to manifest. This means that a dog can have one copy of the mutation and not experience any signs or symptoms of vWD1; this dog would be known as a carrier. The carrier can then pass on either the normal gene or the mutated gene to any offspring. If two carriers are bred, a dog could potentially receive the mutated gene from each parent and be affected by vWD1.
Symptoms include: Abnormal Bleeding, Abnormal Blood Clotting, Bleeding Gums, Blood In The Feces, Blood In The Urine, Easy Bruising, Excessive Bleeding, Hematochezia, Hematoma, Hematuria, Nosebleeds, Vaginal Bleeding.
